Search results for "In vitro assays"

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Comparative analysis of eight cytotoxicity assays evaluated within the ACuteTox Project.

2013

A comparative analysis of eight cytotoxicity assays [the 3T3 and normal human keratinocytes Neutral Red Uptake (NRU) assay, the primary rat hepatocytes, human HepG2 and 3T3 MU assay, and the human A.704, SH-SY5Y and HepG2 cells propidium iodide (PI) assay] included in several work packages of the EU Integrated Project ACuteTox, has been carried out. The aim was to evaluate whether cells originating from liver, kidney and brain provided different in vitro acute toxicity results, and the influence of primary liver cells versus cell lines originated from the same tissue. Spearman rank correlation analysis and Hierarchical Cluster Analysis were performed based on the IC50 (50% inhibitory concen…

Neutral redCell SurvivalCytotoxicityBiologyToxicologyConcentration-response analysischemistry.chemical_compoundMiceCell Line TumorToxicity Tests AcuteAnimalsHumansMTT assayPropidium iodideCytotoxicityCells CulturedAcute toxicityCytotoxinsIn vitro toxicologyCorrelation analysisGeneral Medicine3T3 CellsMolecular biologyAcute toxicityRatsHierarchical Cluster AnalysischemistryCell cultureToxicityImmunologyIn vitro assaysHepatocytesToxicology in vitro : an international journal published in association with BIBRA
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